- 2007: Cast opposite Steve Carell in "Evan Almighty," a sequel to the 2003 comedy "Bruce Almighty"
- 2006: Landed a recurring role on "The New Adventures of Old Christine" (CBS); became a series regular in the second season
- 2006: First HBO Comedy Special, entitled "Wanda Sykes: Sick & Tired"
- 2005: Cast as Jane Fonda's long-suffering personal assistant in the comedy "Monster-in-Law"
- 2004: Starred in her own short-lived Comedy Central show "Wanda Does It"
- 2004: Penned a book of humorous observations on various topics, Yeah, I Said It
- 2003: Appeared in the hour-long Comedy Central special "Tongue Untied"
- 2003: Cast in her own FOX sitcom "Wanda at Large"
- 2002: Voiced a recurring character named Gladys on Comedy Central's puppet show "Crank Yankers"
- 2001: Was a regular on the NBC midseason replacement series "The Downer Channel"
- 2001: Re-teamed with Rock in "Pootie Tang" (based on a sketch from Rock's show) and "Down to Earth"
- 2001: Played a recurring role on Larry David's HBO series "Curb Your Enthusiasm"
- 2000: Acted in "Nutty Professor II: The Klumps"
- 1998: Made film debut in "Tomorrow Night"; directed by "The Chris Rock Show" co-writer, Louis C.K.
- 1997: Joined the writing staff and cast of the HBO series "The Chris Rock Show"
- 1987: Began her stand-up comedy career when she entered a Washington D.C. area talent competition




