- 2008: Featured in Diane English's female ensemble "The Women," a remake of the 1936 play by Clare Boothe Luce
- 2008: Reprised the role of Molly Kagan in the USA series, "The Starter Wife"; earned a Golden Globe nomination for Best Actress in a Comedy Series in 2009
- 2007: Played the lead in the USA mini-series, "The Starter Wife"; earned Emmy, Golden Globe and SAG nominations for Best Actress
- 2006: Voiced forest ranger, Beth in the animated comedy, "Open Season"
- 2005: Starred with Dermot Mulroney in the romantic comedy "The Wedding Date"
- 2004: Cast as Ben Stiller's cheating wife in "Along Came Polly"
- 2004: Voiced Arlene, Garfield's girlfriend in "Garfield: The Movie"
- 2002: Cast opposite Richard Gere in "The Mothman Prophecies"
- 2002: Appeared opposite Woody Allen in "Hollywood Ending"
- 2000: Starred as Mary Magdalene in the CBS miniseries "Jesus"
- 1998: Cast in a small role as a journalist in Woody Allen's "Celebrity"
- 1998: Replaced Sherilyn Fenn in the short-lived ABC series "Prey"
- 1998: Co-starred opposite Eric McCormack in the NBC sitcom "Will & Grace"; earned Emmy (2000, 2001, 2006), Golden Globe (2002, 2003, 2004) and SAG (2004) nominations for Best Actress in a Comedy
- 1997: Made a guest appearance as Jerry's unavailable crush on an episode of "Seinfeld" (NBC)
- 1996: Played the female lead in "McHale's Navy" opposite Tom Arnold
- 1995: Starred as Stacey Colbert, a liberal journalist who enters into a marriage of convenience in the FOX sitcom "Ned and Stacey"
- 1995: Feature film debut in "A Walk in the Clouds"
- 1994: Appeared Off-Broadway in "Four Dogs and a Bone" and "The Naked Truth"
- 1994: Had recurring role of scheming Dana Abandando on "NYPD Blue" (ABC)
- Gained attention of entertainment industry as Harper Pitt in student workshop production of "Angels in America: Perestroika"
- Made professional stage debut in production of "The Importance of Being Earnest" at Seattle's Intiman Theatre
- Raised in East Greenwich, RI




