- 2007: Co-starred with Adam Brody and Meg Ryan in Jonathan Kasdan's directorial debut "In the Land of Women"
- 2006: Co-starred in "3 Needles," one of three short stories about the global HIV pandemic, directed by Thom Fitzgerald
- 2005: Cast in "The Thing About My Folks" penned by and co-starring Paul Reiser
- 2004: Cast in the CBS comedy "Center of the Universe" opposite John Goodman and Ed Asner
- 2002: Co-starred with Janet McTeer and Brenda Fricker in "Innocence," directed by Kristian Levering
- 2001: Had leading role in Timberlake Wertenbaker's stage play "Credible Witness" in London
- 2001: Reprised Anna Madrigal in "Armistead Maupin's Further Tales of the City" (Showtime)
- 2000: Co-starred with Judi Dench in "The Last of the Blonde Bombshells" (HBO), playing an alcoholic saxophone player
- 1999: Made London stage debut in one-person show "Rose", a drama about a Holocaust survivor written by Martin Sherman; opened on Broadway in spring 2000
- 1999: Offered a potent cameo in the CBS miniseries "Joan of Arc"; netted third Emmy nomination
- 1998: Reprised Anna Madrigal in the Showtime sequel "Armistead Maupin's More Tales of the City"; received Emmy nomination
- 1998: Undertook the role of Queen Lear in a distaff retelling of Shakespeare's classic in the stage production "The Lear Project"
- 1997: Appeared as Jennifer Aniston's mother in "Picture Perfect"
- 1996: Returned to the NYC stages in the off-Broadway production of "The Hope Zone"
- 1995: Played the tough principal who mentors Richard Dreyfuss' music teacher in "Mr. Holland's Opus"
- 1995: Made cameo appearance as the mother of a transsexual in "Jeffrey"
- 1995: Appeared on stage as "Hecuba" in a translation by Timberlake Wertenbaker
- 1994: Portrayed Anna Madrigal, the landlady with a penchant for growing marijuana, in "Armistead Maupin's Tales of the City" (PBS)
- 1993: Had rare lead as a Jewish widow in "The Cemetery Club"
- 1992: Cast as matriarch Dolly Sinatra in the CBS miniseries "Sinatra"
- 1991: Portrayed an aging actress desperate for a comeback in "The Last Act Is a Solo" (A&E)
- 1991: Received first Emmy nomination for her supporting performance as the alcoholic mother of a mentally-challenged woman who has won the lottery in "Luck Day" (ABC)
- 1989: Had featured role in the ensemble of "Steel Magnolias"
- 1989: First played Kirstie Alley's mother in "Look Who's Talking"; reprised part in two sequels
- 1987: Breakthrough film role, Rose Castorini, in Norman Jewison's "Moonstruck"
- 1974: TV-movie debut in "Nicky's World"
- 1964: Appeared in Gregory Markopoulos's experimental film "Twice a Man"
- 1964: Feature film debut in "Lilith"
- 1962: Broadway debut, "The Aspern Papers"
- 1961: Began affiliation with the Williamstown Theatre Festival
- 1960: Off-Broadway debut, "The Breaking Wall"
- 1957: Founding member of the Charles Street Playhouse, Boston, Massachusetts
- Appeared regularly on the NBC daytime drama "Search for Tomorrow"
- Founding member and artistic director of The Whole Theater Company, Montclair, New Jersey
- Taught acting at New York University
- Returned to NYU to teach acting




