Family
- father Vernon Vaughn: Divorced from Vaughn's mother in 1991
- mother Sharon Vaughn: Divorced from Vaughn's father in 1991
- sister Victoria Vaughn: Worked as his assistant on "The Break-up" (2006)
- sister Valerie Vaughn:
Companions
- Companion Jennifer Aniston: Rumors of the pair dating began while filming "The Break Up" (2006); they were first spotted kissing at a wrap party in August 2005; relationship troubles were reported in September 2006 with an "official" split in December 2006
- Joey Lauren Adams: became involved during filming of "A Cool, Dry Place" (1999); no longer together
- Companion Kyla Weber: Reportedly dating as of September 2008; rumored to be engaged as of March 2009
