Family
- father Vincent Maguire: Married Maguire's mother c. 1977, but divorced shortly thereafter
- mother Wendy Maguire: Married Maguire's mother c. 1977, but divorced shortly thereafter
- half-siblings : Has four half-brothers and one half-sister
- son Otis Tobias Maguire: Born May 8, 2009; mother, Jennifer Meyer
- daughter Ruby Sweetheart Maguire: Born Nov. 9, 2006; mother, Jennifer Meyer
Companions
- Jennifer Meyer: daughter of Universal Studios president and COO Ron Meyer; rumored to be dating as of 2003
- Kirsten Dunst: reportedly became romantically involved during filming of "Spider-Man" in 2001
- Nicole Kidman: reportedly dating in 2002
- Rashida Jones: daughter of Quincy Jones and Peggy Lipton; no longer together
