- 2007: Helmed the thriller "Eastern Promises," reteaming the acclaimed director with actor, Viggo Mortensen
- 2005: Directed "A History of Violence" a film about an average family that is thrust into the spotlight after the father commits a seemingly self-defense murder
- 2002: Directed Ralph Fiennes and Miranda Richardson in the psychological thriller "Spider"
- 2000: Signed agreement with Internet studio ExFlix to provide content; announced plans to create "David Cronenberg's Film Skool" featuring a character called Rant Quealy
- 1999: Directed first original script in more than 15 years, "eXistenZ"
- 1999: Served as jury president at the Cannes Film Festival
- 1996: Turned another unfilmable novel, J G Ballard's "Crash", into an intriguing, distubing, enigmatic motion picture
- 1993: Reteamed with Irons for "M. Butterfly", a tame, disappointing adaptation of David Henry Hwang's Tony-winning Broadway play
- 1991: Brilliantly adapted William S Burroughs' supposedly unfilmable novel "Naked Lunch"
- 1990: First major acting role in a feature, Clive Barker's "Nightbreed"
- 1988: "Dead Ringers" starred Jeremy Irons in fascinating dual role as twin gynecologists who share each other's lives--and lovers; based on the true story of the Marcus brothers
- 1986: Scored biggest commercial success to date with "The Fly", a reworking of the 1958 cult sci-fi movie starring Jeff Goldblum; made cameo appearance as a gynecologist
- 1985: Acting debut in John Landis' "Into the Night"
- 1983: First feature directed from another's screenplay, "The Dead Zone", based on a Stephen King novel; first Hollywood film
- 1983: Wrote last original screenplay for 16 years, "Videodrome"; starred James Woods in a dynamic performance as head of a soft-core TV channel mesmerized by bizarre, untraceable "snuff" transmissions that have a hallucinatory power
- 1980: Wrote and directed the sci-fi horror flick "Scanners"; among film's assets were the noteworthy special effects; spawned a host of sequels (none of which Cronenberg directed)
- 1979: Used Samantha Eggar's bodily-manifested anger in "The Brood" as a reflection of own anger over divorce from first wife
- 1976: Cast Marilyn Chambers (the "Ivory Snow" porn queen) as a woman with an unsatiable thirst for blood in "Rabid"
- 1974: First commercial feature, "Shivers/They Came from Within/Frissons"; also wrote script
- 1972: Episodic TV directing debut, "Secret Weapons" for the Canadian series "Project X"
- 1972: Made six fillers for TV (directed, scripted, and shot)
- 1972: Returned to Canada
- 1971: While living in France, directed, scripted, and shot three fillers for television
- 1971: Traveled to Europe on Canadian Council Grant
- 1970: Completed second feature, "Crimes of the Future"
- 1969: First feature and first film in 35mm, "Stereo" (produced, directed, wrote, shot and edited)
- 1967: Wrote, directed, shot and edited the 14-minute 16mm short "From the Drain"
- 1966: As a college student, directed, wrote, shot and edited first film, the 16mm, seven-minute short "Transfer"
- Submitted fantasy and science fiction stories to magazines for publication as a youth; none purchased




