Family
- father : edited True Canadian Crime Stories magazine
- sister Denise Cronenberg: has designed costumes for all her brother's features since "The Fly" (1986); studied ballet with the American Ballet Theatre and worked for years as a dancer before changing careers
- daughter Cassandra Cronenberg: served as assistant director trainee on three of father's movies ("Naked Lunch" 1991, "M Butterfly" 1993 and "Crash" 1996); 3rd assistant director on "eXistenZ" (1999); is daughter of David's first wife
- mother :
- son Brandon Cronenberg: born c. 1985; mother, Carolyn Zeifman; worked with father on "eXistenZ"
- nephew Aaron Woodley: son of Denise Cronenberg
- daughter Caitlin Cronenberg: born c. 1991, daughter of Carolyn
Companions
- : first wife, mother of Cassandra; divorced
- wife Carolyn Zeifman: second wife, mother to Caitlin and Brandon
- wife Carolyn Cronenberg:
