- 2009: Nominated for the 2009 Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series
- 2008: Joined Rainn Wilson in the comedy "The Rocker"
- 2007: Played a 30-year-old psychiatrist who suffered from amnesia in the ABC comedy, "Samantha Who?"; also produced; earned Golden Globe (2008, 2009), SAG (2008, 2009) and Emmy (2008, 2009) nominations for Best Actress in a Comedy Series
- 2005: Made her Broadway debut as Charity Hope Valentine in "Sweet Charity"; received a Tony nomination for her role
- 2005: Co-starred with husband Johnathon Schaech in the CBS movie "James Patterson's Suzanne's Diary for Nicholas"
- 2004: Starred opposite Will Ferrell as an ambitious female journalist in the comedy "Anchorman"
- 2004: Received an Emmy nomination for Outstanding Guest Actress in a Comedy series for her role on "Friends"
- 2003: Appeared alongside Gwyneth Paltrow as flight attendants in the comedy "A View from the Top"
- 2002: Had a recurring role as Rachel's sister in the NBC comedy "Friends"
- 2002: Co-starred with Cameron Diaz and Selma Blair in the comedy "The Sweetest Thing"
- 2001: Had dual role in the comedy "Just Visiting," playing a 12th-century noblewoman and her 21st-century descendant
- 2000: Co-starred with Johnathon Schaech and Molly Ringwald in "The Giving Tree"
- 1998: Returned to series TV as the lead in the NBC sitcom "Jesse"
- 1998: Co-starred with Mark Wahlberg and Lou Diamond Phillips in "The Big Hit"
- 1998: Starred in the independent feature "Claudine's Return"
- 1996: Cast in Tim Burton's "Mars Attacks!"
- 1991: Had starring role in "Don't Tell Mom the Babysitter's Dead"
- 1990: Feature lead in "Streets"
- 1987: Cast as ditzy teenager, Kelly Bundy on Fox's "Married... With Children"
- 1986: TV series debut in "Hearts of the City"
- 1983: Made TV movie debut in "Grace Kelly"
- 1979: Made film debut in "Jaws of Satan"
- 1971: Made TV debut at the age of three months in "Days of Our Lives"
- First TV speaking role in "Quincy"




