Family
- mother Nancy Priddy: Divorced from Applegate's father
- father Robert Applegate: Divorced from Applegate's mother; remarried
- half-sister Alisa: Born c. 1977
- half-brother Kyle: Born c. 1982
Companions
- Companion Martyn LeNoble: Dating since 2008
- husband Jonathan Schaech: dating since c. January 1998; married on October 20, 2001
- Companion Lee Grivas: Dated following her separation from Schaech; died on July 1, 2008 of an apparent drug overdose; were not together at the time of his death
