- 2009: Returned to the stage for the Broadway production of Yasmina Reza’s "God of Carnage"; earned a Tony Award nomination for Best Actor in a Play
- 2007: Played Joseph Gordon-Levitt's blind roommate in the crime thriller, "The Lookout"
- 2006: Starred in the Truman Capote biopic, "Infamous"
- 2005: Co-starred with Laura Linney in Noah Baumbach's "The Squid and the Whale"; earned Independent Spirit and Golden Globe nominations for Best Actor
- 2005: Co-starred in the George Clooney-directed “Goodnight, and Good Luck,” a 1950s-era drama that chronicles broadcaster Edward R. Murrow’s campaign to bring down Senator Joseph McCarthy
- 2004: Appeared with Sigourney Weaver in the family drama "Imaginary Heroes"
- 2003: Starred as Lt. Col. Joshua Chamberlain - the same role he played in "Gettysburg" - in the Civil War drama "Gods and Generals"
- 2002: Had a small but pivotal role as Ed Harris' ex-lover in "The Hours"
- 2002: Co-starred with Clint Eastwood in the detective thriller "Blood Work"
- 2001: Feature directorial debut, "Escanaba in da Moonlight"; also scripted from his play and starred
- 2000: Played a teacher who assisted his students in cheating in the HBO film, "Cheaters"
- 2000: Portrayed George Washington in the A&E original film, "The Crossing"
- 1999: NYC debut as playwright, "Thy Kingdom's Come"
- 1998: Co-starred in Gary Ross' Academy Award-nominated film, "Pleasantville"
- 1996: Co-starred with Glenn Close in the live action feature, "101 Dalmatians"
- 1995: Reprised stage role in the CBS TV adaptation of "Redwood Curtain"
- 1994: Had a pivotal role as Keanu Reeves' partner in the hit film "Speed"
- 1994: Co-starred with Jim Carrey in the commercial hit, "Dumb and Dumber"
- 1993: Returned to the Broadway stage in "Redwood Curtain"; penned by Lanford Wilson
- 1993: Starred as Lt. Col. Joshua Chamberlain in the Civil War ensemble "Gettysburg"
- 1990: Founded the regional theater, Purple Rose Theater Company in Chelsea, MI
- 1989: Played guitar on Don Johnson's album, Let It Roll
- 1986: Received critical praise for his turn in Jonathan Demme's "Something Wild"
- 1985: Played first full-fledged romantic lead in Woody Allen's "The Purple Rose of Cairo"
- 1983: First prominent film role as Flap, Debra Winger's cheating husband in James L Brooks' "Terms of Endearment"
- 1982: Played first leading role on TV in the NBC adventure pilot, "Catalina C-Lab"
- 1982: Starred in one-person Off-Broadway show "Johnny Got His Gun"
- 1981: Feature acting debut, a bit part in Miloš Forman's "Ragtime"
- 1980: Made Broadway debut reprising the role of Jed for "Fifth of July"
- 1980: TV acting debut in the CBS miniseries, "A Rumor of War"
- 1978: Originated the role of Jed in "Fifth of July"; role written expressly for Daniels by playwright Lanford Wilson
- 1976: First NYC stage appearance, "The Farm"
- Worked as an apprentice with the Circle Repertory Theater in New York City
- Raised in Southeastern Michigan




