- 2007: Reprised role of Puss in Boots for "Shrek the Third"
- 2007: Cast opposite Jennifer Lopez in "Bordertown"
- 2006: Played a former professional dancer in the musical-drama "Take the Lead"
- 2006: Directed second feature, the Spanish-language production "El Camino de los Ingleses/The English Path"
- 2005: Reteamed with Catherine Zeta-Jones and director Martin Campbell for "The Legend of Zorro"
- 2004: Voiced the character Puss-in-Boots, opposite Mike Myers and Cameron Diaz for "Shrek 2"
- 2003: Returned to his role as Gregorio Cortez in "Spy Kids 3D: Game Over"
- 2003: Portrayed Pancho Villa in the HBO movie "And Starring Poncho Villa as Himself"; received a Golden Globe and an Emmy nomination for Best Actor in a Miniseries or movie (2004)
- 2003: Made Broadway debut in a revival of the award-winning musical "Nine"
- 2003: Reteamed with director Robert Rodriguez for "Once Upon a Time in Mexico" the third in an unofficial trilogy begun with "El Mariachi"
- 2002: Co-starred opposite Rebecca Romijn-Stamos in "Femme Fatale"
- 2002: Reprised role of espionage agent and parent in "Spy Kids 2"
- 2002: Co-starred in the bio pic feature "Frida"
- 2001: Reteamed with Robert Rodriguez to play a retired espionage agent who comes out of retirement in "Spy Kids"
- 2001: Had leading role opposite Angelina Jolie in "Original Sin"
- 2000: Reteamed with Glimcher for "The White River Kid" (filmed in 1998); aired on Starz! in lieu of a theatrical release
- 2000: Starred opposite Woody Harrelson as professional boxing rivals in Ron Shelton's "Play It to the Bone"
- 1999: Feature directorial debut, "Crazy in Alabama", starring Griffith; also produced
- 1998: Starred alongside Anthony Hopkins in "The Mask of Zorro"; Martin Campbell replaced Rodriguez as director
- 1996: Played Che in the film musical "Evita", opposite Madonna
- 1995: Co-starred with future wife Melanie Griffith in "Two Much"
- 1995: First leading role in Hollywood film, Robert Rodriguez's "Desperado"
- 1994: Acted in "Of Love and Shadows", another picture adapted from a work by Allende
- 1994: Portrayed sinister gay bloodsucker Armand in Neil Jordan's film adaptation of "Interview with the Vampire"
- 1993: Played hunks in two high profile films: opposite Glenn Close and Winona Ryder in "The House of the Spirits" (based on the Isabel Allende novel) and as Tom Hanks' lover in "Philadelphia"
- 1993: Reteamed with Saura for "Outrage"
- 1992: Acted in first Hollywood film, Arne Glimcher's "The Mambo Kings"; had to learn the entire script phonetically, and the fact that he did not understand what he was saying showed
- 1991: Appeared as himself in Madonna's tour documentary "Truth or Dare"; the 'Material Girl' gave his career a big boost by publicly (and unrequitedly) lusting after him
- 1990: Starred opposite Abril in Almodovar's "Tie Me Up! Tie Me Down!"; last collaboration to date with the director (left cast of 1991's "High Heels" to do "Mambo Kings"); fourth film with Abril
- 1988: Played gigolo opposite Maura's wealthy, sexually dysfunctional woman in Rafael Moleon's (former assistant to Almodovar) feature directing debut, "Baton Rouge"; fourth film with Maura; Victoria Abril also starred
- 1988: Co-starred in Almodovar's "Women on the Verge of a Nervous Breakdown", starring Maura; then-wife Ana Leza also in cast
- 1987: Third film with Almodovar, "Law of Desire", cast him as a heterosexual discovering homosexual love
- 1986: Reteamed with Almodovar for "Matador"; first film with Carmen Maura
- 1984: Acted in Carlos Saura's "Los Zancos/The Stilts"
- 1982: Feature film debut, "Labyrinth of Passion" (released in the USA in 1990); first collaboration with Pedro Almodovar
- 1981: Worked for five years as an ensemble member of Spain's National Theater
- 1981: Made professional stage debut in "Los Tarantos"
- 1980: Moved to Madrid; worked as a waiter and department store clerk while trying to get acting jobs (date approximate)
- 1974: Began career working with independent theater company in home town of Malaga at age 14, having abandoned dreams of playing professional soccer after breaking foot
- Formed Green Moon Productions, deriving its name from Federico Garcia Lorca's declaration that "Andalusians are not dark from the sun, but from the green moon"
- Formed theater troupe and traveled around southern Spain in an old truck putting on street productions




