- 2009: Nominated for the 2009 Primetime Emmy Award for Outstanding Lead Actress In A Miniseries Or A Movie
- 2009: Played a devout Christian who came to terms with her son's homosexuality after his suicide in the Lifetime movie "Prayers for Bobby"; earned an Emmy nomination for Best Actress in a Television Movie
- 2008: Cast opposite Tina Fey and Amy Poehler in the comedy, "Baby Mama"
- 2008: Cast as a news producer in the thriller, "Vantage Point"
- 2007: Cast in the network satire "The TV Set" directed by Jake Kasdan and starring David Duchovny
- 2007: Portrayed an autistic woman, opposite Alan Rickman in "Snow Cake"
- 2006: Played a Manhattan socialite in the Truman Capote biopic "Infamous"
- 2004: Starred with Jeff Daniels in the family drama "Imaginary Heroes"
- 2004: Starred in M. Night Shyamalan's "The Village" with William Hurt and Joaquin Phoenix
- 2003: Starred in the play-turned-motion picture drama "The Guys"
- 2003: Was the warden in the teen feature "Holes"
- 2002: Returned to the NYC stage in "The Guys"; performed Off-Off-Broadway at the Flea, a company run by her husband
- 2002: Played Eve, a woman whose 16 year old stepson falls in love with her in "Tadpole"
- 2001: With Jennifer Love Hewitt, played a mother-daughter con team in "Heartbreakers"
- 2001: Had featured role in "Company Man"
- 1999: Received star on the Hollywood Walk of Fame (December 16)
- 1999: Teamed with Julianne Moore for the screen version of the novel "A Map of the World"
- 1997: TV-movie debut as the wicked stepmother in "Snow White: A Tale of Terror" (original intended for theatrical release but aired on Showtime); earned an Emmy nomination
- 1997: Played a clone of Ripley in "Alien Resurrection"
- 1997: Re-teamed with Kline in Ang Lee's mood piece "The Ice Storm"
- 1996: Returned to Broadway as the star of Christopher Durang's "Sex and Longing"
- 1995: Appeared as an agoraphobic psychologist in "Copycat" opposite Holly Hunter
- 1993: First onscreen teaming with Kevin Kline in "Dave"
- 1992: Again reprised Ripley for David Fincher's "Alien3"; debuted as a producer
- 1989: Reprised role of Dana Barrett in "Ghostbusters II"
- 1988: Portrayed gorilla conservationist Dian Fossey in "Gorillas in the Mist"; received one of two Oscar nominations that year for Best Actress; became the first actor nominated in two categories not to win either
- 1988: Portrayed a ruthless business woman in "Working Girl"; received one of two Oscar nominations that year for Best Supporting Actress; became the first actor nominated in two categories not to win either
- 1986: Reprised her role as Ripley in James Cameron's "Aliens"; earned an Oscar nomination for Best Actress
- 1984: Co-starred in the Broadway production of "Hurlyburly"; directed by Mike Nichols; received a Tony nomination
- 1984: Had female lead of Dana Barrett in the blockbuster comedy "Ghostbusters"
- 1982: Co-starred opposite Mel Gibson in Peter Weir's "The Year of Living Dangerously"
- 1979: Breakthrough film role as Ripley in Ridley Scott's "Alien"
- 1977: Had bit part as Woody Allen's movie date in "Annie Hall"
- 1976: TV debut as a regular on the NBC soap "Somerset"; appeared alongside Ted Danson and JoBeth Williams
- 1976: With Durang, co-wrote and co-starred in "Das Lusitania Songspiel"; produced off-off-Broadway
- 1976: Film acting debut in "Madman" (Israel)
- 1974: Broadway debut (as understudy) in "The Constant Wife"
- 1974: Appeared with Meryl Streep in the chorus of the Stephen Sondheim adaptation of "The Frogs" performed at Yale
- 1971: After attending Stanford, moved to Israel and lived on a kibbutz
- 1965: Made early stage appearances in Southbury, CT
- 1963: Began using the name Sigourney (after a character mentioned in "The Great Gatsby")
- Returned to the US and enrolled at Yale
- Off-Broadway debut in Christopher Durang's "The Nature and Purpose of the Universe"
- Formed Goat Cay Productions




