Family
- mother Marilyn Hoffman Connor: Divorced from Hoffman's father
- sister Jill Hoffman: Older
- sister Emily Hoffman: Younger
- daughter Talluhlah Hoffman: Born November 2006; mother, Mimi O'Donnell
- father Gordon Hoffman: Divorced from Hoffman's mother
- brother Gordy Hoffman: Won the Waldo Salt Award at the Sundance Film Festival for "Love Liza" (2002)
- son Cooper Alexander Hoffman: Born in March 2003; mother, Mimi O'Donnell
Companions
- Companion Mimi O'Donnell: Met while working on the 1999 play "In Arabia We'd All Be Kings," which Hoffman directed
