- 2009: Re-teamed with Meryl Streep to direct "Julie & Julia"; also penned the screenplay adaptation of Julie Powell's book about cooking 524 recipes from Child's Mastering the Art of French Cooking
- 2005: Directed the big-screen adaptation of the classic 60's TV show, "Bewitched"; also produced and co-wrote with sister Delia
- 2002: Scripted first play, "Imaginary Friends," about the relationship between writers Lillian Hellman and Mary McCarthy; first premiered at the Old Globe Theatre in San Diego, before moving to Broadway's Ethel Barrymore Theatre
- 2000: Produced and co-wrote screenplay (with sister Delia) for "Hanging Up"; directed by Diane Keaton, who also co-starred
- 1998: Re-teamed with Tom Hanks and Meg Ryan for "You've Got Mail"; co-wrote with sister Delia
- 1996: Produced and directed the comedy, "Michael"; also co-wrote with sister Delia
- 1994: Directed the critically panned, "Mixed Nuts"; re-teamed with sister Delia to write the screenplay
- 1993: Re-teamed with Meg Ryan to direct her in the hit romantic comedy, "Sleepless in Seattle"; also co-wrote, earning third Best Original Screenplay Academy Award nomination
- 1992: Directed first feature, "This Is My Life"; also co-wrote with sister Delia Ephron
- 1992: Played a party guest in Woody Allen's "Husbands and Wives"
- 1989: Had a small role as a wedding guest in Woody Allen's "Crimes and Misdemeanors"
- 1989: Garnered second Academy Award nomination for writing "When Harry Met Sally..."; directed by Rob Reiner and starred Billy Crystal and Meg Ryan
- 1986: Penned screenplay adaptation of "Heartburn"; directed by Mike Nichols and starred Meryl Streep and Jack Nicholson
- 1983: Published first novel, Heartburn, which was loosely based on the break-up of her second marriage to Carl Bernstein
- 1983: Co-wrote first screenplay, "Silkwood"; earned first Academy Award nomination for Best Original Screenplay
- 1978: Wrote the teleplay "Perfect Gentlemen" for CBS
- 1975: Published second collection of essays, Crazy Salad: Some Things About Women
- 1974: Promoted to senior editor at Esquire magazine
- 1973: Wrote for the short-lived ABC sitcom "Adam's Rib"
- 1972: Named a columnist and contributing editor at Esquire magazine
- 1970: Published first collection of essays, Wallflower at the Orgy
- 1963: Worked as reporter for the New York Post
- 1944: Moved with parents to Beverly Hills, CA at age three
- Was contributing editor at New York magazine
- Was a freelance writer, contributing to such publications as The New York Times Magazine and Good Housekeeping
- Parents reportedly used her college letters to home as the inspiration for the 1961 Broadway hit "Take Her, She's Mine" (filmed in 1963)




