Family
- mother Encarna Cruz: Runs Cruz's business affairs
- father Eduardo Cruz:
- sister Monica Cruz: Born c. 1977; former professional flemenco dancer; achieved fame in the youth-oriented TV series "Un Paso Adelante"
- brother Eduardo Cruz Jr: Born c. 1985
Companions
- Companion Matthew McConaughey: Met while filming "Sahara" (2005); together from 2004-2006
- Companion Tom Cruise: Met when co-starring in "Vanilla Sky" (2001); went public with relationship in July 2001; had a three-year relationship which ended in January 2004
- Companion Javier Bardem: Reportedly dating as of summer 2007; co-starred together in"Vicki Cristina Barcelona" (2008)
- Companion Orlando Bloom: Rumored to have briefly dated in 2006
- Companion Tomas Obermaier: Czech; became involved during filming of "La Nina de tus Ojos/The Girl of Your Dreams" (1998); together from 1998-2000
- Enrique Sarasola: competed in the Olympics; together from c. 1997 to c. 1998
- Nacho Cano: appeared with group Mecano; together from c. 1991 to c. 1997
- Tom Cruise: worked together on "Vanilla Sky"; went public with relationship in July 2001
- Tomas Obermajer: Czech; became involved during filming of "La Nina de tus Ojos/The Girl of Your Dreams"; had two-and-a-half-year relationship c. 1998 to c. 2000
- Companion Enrique Sarasola: Competed in the Olympics; together from 1997-1998
