Family
- father Norman Dreyfus: Later became a restaurateur
- mother Gerry Dreyfus: Appeared in two films with son, "Down and Out in Beverly Hills" (1986) portraying his mother, and "Let It Ride" (1989); died Oct. 19, 2000 from complications of a stroke
- daughter Emily Dreyfuss: Born in November 1983; mother, Jeramie Rain
- son Benjamin Dreyfuss: Born in June 1986; mother, Jeramie Rain; was born with a condition called Peter's anomaly, an abnormality in which his cornea was fused with his iris leaving him permanently blind in one eye
- son Harry Spencer Dreyfuss: Born Aug. 9, 1990; mother, Jeramie Rain
Companions
- wife Jeramie Rain: Met at a party c. 1983; married from 1983-1995; mother of his three children; suffered a flare up of systemic lupus erythematosus after birth of their first child Emily; originally diagnosed at age 29
- wife Janelle Lacey: announced engagement in May 1998; married on May 30, 1999
- Laura Cayouette: together from c. 1993 to 1996; born c. 1964; daughter of NSA deputy director William Crowell
- wife Svetlana Erokhin: Russian-born; married March 16, 2006
- wife Janelle Lacey: Married May 30, 1999, but are now divorced
