- 2004: Once again portrayed a vampire hunter in "Blade: Trinity"; also produced
- 2002: Reprised role (also produced) in "Blade II"
- 2000: Produced and starred in the thriller "The Art of War"
- 1998: Played an African-American superhero who battles a group of blood-sucking vampires in "Blade"
- 1998: Made his network TV debut as producer and star of "Futuresport" (ABC)
- 1998: Cast as the escaped con purused by Tommy Lee Jones in "U.S. Marshall"
- 1998: Produced Che-Kirk Wong's "The Big Hit"; film starred Mark Walhlberg and Lou Diamond Phillips
- 1998: Produced and acted in Maya Angelou's directorial debut, "Down in the Delta"
- 1998: Received star on the Hollywood Walk of Fame (August 21)
- 1997: Played a detective investigating "Murder at 1600"
- 1997: Won praise for his turn as an unfaithful husband in "One Night Stand"
- 1996: Was one of several prominent showbiz figures to provide funding for Lee's "Get on the Bus"
- 1996: Executive produced (also narrated) the documentary, "John Henrik Clarke: A Great and Mighty Walk"
- 1996: Starred opposite Robert De Niro in "The Fan"
- 1995: Donned drag to play Noxeema Jackson in "To Wong Foo, Thanks for Everything, Julie Newmar"
- 1995: Reteamed with Harrelson for "Money Train"
- 1993: Co-starred with Sean Connery in the film adaptation of Michael Crichton's "Rising Sun"
- 1992: Reteamed with Woody Harelson in Ron Shelton's "White Men Can't Jump"
- 1991: Played merciless drug lord Nino Brown in Mario Van Peebles' controversial "New Jack City"
- 1991: Reteamed with Lee for the interracial romance "Jungle Fever"
- 1990: Cast as a regular in the short-lived ABC cop series, "H.E.L.P."
- 1988: TV debut in the HBO anthology miniseries, "Vietnam War Story"
- 1988: Turned down a small role in Lee's "Do the Right Thing" for the larger part of Willie Mays Hays in "Major League" (1989)
- 1987: Appeared as Michael Jackson's rival gang leader in the Martin Scorsese-directed music video "Bad" (only seen in the long version of the video)
- 1986: Film debut in the Goldie Hawn vehicle "Wildcats"; first collaboration with Woody Harrelson
- 1985: Broadway debut in "The Boys of Winter"
- 1977: Moved back to Orlando, Florida, with his mother
- 1963: Moved to the Bronx at age one
- 1900: Portrayed jazz saxaphonist Shadow Henderson in Lee's "Mo' Better Blues"
- Appeared in the East Harlem production of "The Me Nobody Knows"
- Co-founded Struttin' Street Stuff, a theater troupe which performed street and puppet theater in Orlando
- Appeared in commercials for Levi's 501 jeans and Coca-Cola Classic
- Appeared in "The Wiz" with Theatre on Park Dinner Theatre in Orlando
- Founded Amen Ra Films in conjunction with Fox
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