Family
- father Emilio Diaz: Second-generation Cuban/American; appeared as a prisoner in "There's Something About Mary" (1998); died April 15, 2008 of pneumonia at age 58
- mother Billie Diaz: Of Native American, German and English descent
- sister Chimene A Diaz: Born in 1970
Companions
- Companion Justin Timberlake: Met at the 2003 Kids' Choice Awards; together from June 2003 to December 2006
- Carlos de la Torre: born in 1967; together from 1990 to 1995
- Jared Leto: dating as of 1999
- Matt Dillon: together from 1996; reportedly separated as of September 1998
- Sam Mendes: reportedly dated; no longer together
- Companion Paul Sculfor: Began dating in Summer 2008; previously dated Jennifer Aniston
