Family
- father Dominic Pantoliano: separated from Pantoliano's mother c. 1963; divorced
- mother Mary Isabella: separated from Pantoliano's father c. 1963; divorced
- step-father Florio Isabella: had ties to the underworld; spent 15 years in jail on drug trafficking charges before marrying Pantoliano's mother
- sister Mary Ann Pantoliano: younger
- step-daughter Melody: born c. 1985 mother, Nancy Sheppard
- son Marco Pantoliano: born c. 1981; mother, first wife
- daughter Daniella Pantoliano: born on March 8, 1992; mother, Nancy Sheppard
- daughter Isabella Grace Pantoliano: born on August 27, 1998; mother, Nancy Sheppard
