- 2008: Co-starred in Paul W.S. Anderson's remake of the 1975 film "Death Race"
- 2008: Co-starred in the drama, "Bonneville" with Kathy Bates and Jessica Lange
- 2007: Reprised her role as Pamela Landy in "The Bourne Ultimatum" starring Matt Damon
- 2005: Starred as an alcoholic single mother of four in Mike Binder's "The Upside of Anger"; screened at sundance
- 2005: Starred as an Irish-American scientist who begins a passionate love affair with Middle-Eastern man in Sally Potter's "Yes"
- 2005: Starred with Sam Elliott in "Off the Map" directed by Campbell Scott
- 2004: Starred as CIA director, Pamela Landy in "The Bourne Supremacy" based on the novel by Robert Ludlum
- 2004: Featured in the film "The Notebook" directed by Nick Cassavetes
- 2001: Cast alongside Anjelica Huston and Samantha Mathis in the TNT miniseries "The Mists of Avalon"
- 2000: Starred in the fictionalized biopic of slain Irish journalist Veronica Guerin, "Though the Sky Falls" (aired in USA on Cinemax)
- 2000: Portrayed a prospective US Vice President stained by a sexual scandal in "The Contender"; reteamed with Jeff Bridges who played the US President; earned a Best Actress Oscar nomination
- 1999: Provided a voice for "New York: A Documentary Film" (PBS' "The American Experience")
- 1999: Had featured role as Daniels' wife in "It's the Rage/All the Rage"; screened at the Toronto Film Festival
- 1998: Played yet another repressed housewife who blossoms in the satirical "Pleasantville"; first film with Jeff Daniels; played sitcom mother whose "son" was portrayed by Tobey Maguire
- 1997: Portrayed John Travolta's wife in "Face/Off"
- 1997: Co-starred with Kevin Kline in Ang Lee's "The Ice Storm"; played Tobey Maguire's mother
- 1996: Earned second Best Supporting Actress Oscar nomination for her performance as Daniel Day-Lewis' severe wife in "The Crucible"
- 1995: Breakthrough screen role as Pat Nixon in Oliver Stone's biopic "Nixon"; earned first Academy Award nomination as Best Supporting Actress
- 1993: Played mother of young chess prodigy (and Joe Mantegna's wife) in "Searching for Bobby Fischer"
- 1991: Essayed the role of Sarah Brady (wife of James Brady) in HBO's "Without Warning: The James Brady Story" co-starring Beau Bridges
- 1989: Was Emily Lloyd's mother in Norman Jewison's "In Country"
- 1988: Portrayed Jeff Bridges' wife in Coppola's "Tucker: The Man and His Dream"
- 1988: Nominated for a Tony as Heidi Holland in Wendy Wasserstein's "The Heidi Chronicles"; appeared opposite future husband Peter Friedman
- 1987: Starred as Ann Deever in "American Playhouse" presentation of Arthur Miller's "All My Sons" (PBS)
- 1987: Broadway debut, "Burn This"; co-starred with John Malkovich; won a Tony for Best Actress
- 1986: First film with director Francis Ford Coppola, "Peggy Sue Got Married"
- 1985: TV debut in miniseries, "Evergreen" (NBC); her character aged from a teenager to a 50-year-old
- 1985: Screen acting debut, "Compromising Positions"
- 1983: Made Off-Broadway debut in a New York production of "And a Nightingale Sang"
- 1978: Accepted John Malkovich's invitation to join Chicago's Steppenwolf Theatre
- Worked as secretary at an educational film company
- Turned to drama in high school after failing to make it as a cheerleader




