Family
- father Robert Wilson: Operated a public television station
- mother Laura Wilson:
- brother Andrew Wilson: Born in 1963; co-starred with brothers Luke and Owen in "Bottle Rocket" (1996); co-directed "The Wendell Baker Story" (2005) with Luke
- brother Owen Wilson: Born in 1968; co-starred with brother Luke in "Bottle Rocket" (1996), "The Royal Tenenbaums" (2001) and "The Wendell Baker Story" (2005)
Companions
- Drew Barrymore: appeared together in "Best Men" and "Home Fries"; together from 1996 to c. 1998
- Gwyneth Paltrow: began dating as of spring 2001; met during filming of "The Royal Tenenbaums"; no longer together
- Companion Soundis: Began dating in June 2003; no longer together
- Companion Andrea Wilson: Works at Lisa Kline boutique; had an on again off again relationship since 2004; no longer together
- Companion Meg Simpson: Reportedly dating as of October 2008
