- 2009: Took a serious turn with the dramady, "Funny People"; wrote, directed and produced the film that stars Adam Sandler, Seth Rogen and wife Leslie Mann
- 2008: Co-wrote and co-produced the comedy "Pineapple Express"
- 2007: Co-wrote the music and lyrics for "Walk Hard" from the film, "Walk Hard: The Dewey Cox Story"; earned a Golden Globe nomination for Best Original Song for a Motion Picture and a Grammy nomination for Best Song
- 2007: Helmed the comedy "Knocked Up" about an insensitive slacker who impregnates a girl after a one-night stand
- 2007: Produced the film "Superbad," which was co-penned by frequent collaborator, Seth Rogen
- 2005: Made directorial debut with the comedy "The 40 Year-Old Virgin" starring Steve Carell; also co-wrote the film with Steve Carell
- 2004: Produced "Anchorman: The Legend of Ron Burgundy" starring Will Ferrell; also cast in a small role
- 2001: With Feig, created the Fox series "Undeclared," about freshmen college students; also served as executive producer
- 1999: Served as executive producer of the NBC drama "Freaks and Geeks"; initial collaboration with Paul Feig
- 1996: First solo screenwriting credit, "Celtic Pride"; also executive produced
- 1996: Sued Writers Guild of America for writing credit on "The Cable Guy"; also served as a producer; suit later withdrawn
- 1995: First film as executive producer and co-screenwriter, "Heavyweights"; also played bit part
- 1994: Wrote for the annual telecast of the Grammy Awards
- 1994: Produced and wrote for the animated series "The Critic" (Fox)
- 1992: First film as associate producer, "Crossing the Bridge"
- 1992: Created, produced, wrote for and appeared in "The Ben Stiller Show" (Fox); won Emmy for writing
- 1992: Series debut as writer and consulting producer, "The Larry Sanders Show" (HBO)
- 1991: TV debut as writer, "Tom Arnold: The Naked Truth" (HBO)
- 1988: TV debut as performer, "Comic Strip Live" (Fox)
- 1985: Made debut as stand-up comic in Long Island
- 1982: At age 16, worked as a dishwasher at the Eastside Comedy Club in Huntington, New York (date approximate)
- 1982: Hosted own radio show at his high school; interviewed such comedians as Jerry Seinfeld, Jay Leno and Martin Short
- Worked as a joke writer for both Roseanne and Tom Arnold, as well as Jim Carrey
- Raised near Syosset, NY
- Formed Apatow Productions; signed two-year, first look deal with New Line




