- 2008: Nominated for the 2008 Independent Spirit Award for Best Male Lead (“Vicky Cristina Barcelona”)
- 2008: Co-starred with Penélope Cruz and Scarlett Johansson in Woody Allen's "Vicky Cristina Barcelona"
- 2008: Nominated for the 2008 Golden Globe Award for Best Performance by an Actor in a Motion Picture – Musical or Comedy (“Vicky Cristina Barcelona”)
- 2007: Played the sinister monk, Brother Lorenzo in Milos Forman's "Goya's Ghosts"
- 2007: Played a lovesick romantic in Mike Newell's adaptation of "Love in the Time of Cholera"
- 2007: Offered an award winning performance as a murderous drug runner in the Coen brothers' "No Country for Old Men"
- 2005: Cast in Andy Garcia's independent film "The Lost City," centered around a club owner in Havana, Cuba, during the 50's
- 2004: Starred in "Mar Adentro/The Sea Inside" about the Life story of Spaniard Ramón Sampedro, who fought a 30-year campaign to win the right to end his life with dignity; received a Golden Globe nomination for Best Lead Actor (Drama)
- 2004: Appeared opposite Tom Cruise in the thriller "Collateral"
- 2003: Co-starred in the award-winning feature "Monday's in the Sun"
- 2002: Had featured role in "The Dancer Upstairs", directed by John Malkovich; screened at Sundance
- 2000: Starred as Cuban writer Reinaldo Arenas in "Before Night Falls"; received Best Actor Academy Award nomination
- 1999: Served as executive producer and star of "Los Lobos de Washington"
- 1997: English-language debut opposite Rosie Perez in "Perdita Durango"
- 1997: Reteamed with Almodovar for "Live Flesh"
- 1995: Starred in "Mouth to Mouth/Boca a Boca"; released in USA in 1997
- 1994: Delivered change of pace turns in "The Detective and Death/El Detective y la Muerte" and "Numbered Days/Dias Contados"
- 1993: Portrayed an oversexed man in Luna's "Golden Balls/Huevos de Oro"
- 1992: Reteamed with direcor Luna for "Jamon, Jamon"
- 1991: Co-starred in Pedro Almodovar's "High Heels"
- 1990: Film debut, "The Ages of Lulu", directed by Bigas Luna




