- 2006: Directed third feature "Science of Sleep," starring Gael Garcia Bernal as a man trying to take control of his dreams
- 2006: Directed "Dave Chappelle's Block Party" a mix of Chappelle's sketch comedy and musical interludes, inspired in part by the 1973 documentary Wattstax
- 2004: Once again teamed with Charlie Kaufman to direct "Eternal Sunshine of the Spotless Mind" starring Jim Carrey and Kate Winslet
- 2002: Charlie Kaufman's "Human Nature" marked his feature directing debut
- 1994: Directed the Levi's ad "Drugstore"; garnered the Lion D'Or at Cannes; listed in the Guinness Book of World Records as the most award-winning commercial of all time
- 1993: Developed a long collaboration with pop singer Björk, by first directing her video "Human Behavior"; won all major music video awards
- Began directing videos for the puck rock band Oui Oui, for which he played drums
- Collaborated with artists such as The Rolling Stones, Foo Fighters, Lenny Kravitz, and Sheryl Crow
- Directed a series of spots for Gap's lyrical "That's Holiday" campaign
- Made a minute-long cartoon at the age of 12, with the help of a toy Meccano machine




