- 2008: Co-starred with Seth Rogen as the eponymous female lead in the Kevin Smith comedy, "Zack and Miri Make a Porno"
- 2008: Cast as the female lead in the dark comedy "Meet Bill" alongside Aaron Eckhart
- 2008: Portrayed First Lady Laura Bush in Oliver Stone's biopic "W." on the life of President George W. Bush
- 2007: Reprised role of Betty Brant for "Spider-Man 3"
- 2007: Co-starred with Vince Vaughn and Paul Giamatti in the comedy "Fred Claus"
- 2006: Cast as Mark Wahlberg's love interest in "Invincible"; based on the true story of Eagles football player Vince Papale
- 2006: Appeared in the season five finale of the NBC sitcom "Scrubs" as the love interest to J.D. (Zach Braff); had a recurring role in season six
- 2005: Cast opposite Steve Carrell in the Judd Apatow comedy "The 40-Year Old Virgin"
- 2004: Again portrayed Betty Brant in "Spider-Man 2"
- 2003: Breakout role as Jeff Bridges' wife in the Gary Ross directed "Seabiscuit"
- 2002: Cast as Betty Brant in the blockbuster hit "Spider-Man"
- 2002: Appeared in Steven Spielberg's "Catch Me If Your Can" opposite Leonardo DiCaprio
- 2001: Appeared in the cult comedy, "Wet Hot American Summer"
- 2000: Cast in a small role in John Singleton's "Shaft"
- 1999: TV debut, an episode of the NBC drama "Third Watch"
- 1998: First film role, the independent drama "Surrender Dorothy" (credited as Elizabeth Casey)




