Family
- father Harry Hyra: Divorced from Ryan's mother in 1976
- mother Susan Hyra: Divorced from Ryan's father in 1976; reportedly got Ryan an audition for "Rich and Famous" (1981), director George Cukor's final film; has been estranged from Ryan since the late 1980s
- step-father Pat Jordan:
- son Jack Henry Quaid: Born April 24, 1992; father, Dennis Quaid
- daughter Daisy Ryan: Adopted from China in January 2006
- brother Andrew Hyra: Member of Billy Pilgrim, an American folk rock duo
- sister Annie Hyra:
- sister Dana Hyra:
Companions
- Craig Bierko: reportedly dating as of early 2002
- Russell Crowe: began highly publicized relationship during filming of "Proof of Life" in 2000; separated in December 2000
