- 2008: Played Inez Scull in the CBS mini-series of Larry McMurtry's "Comanche Moon"
- 2006: Cast as part of an ensemble in the ABC drama "Brothers and Sisters" playing the eldest sibling; earned Emmy (2007, 2008) and Golden Globe (2008, 2009) nominations for Best Supporting Actress in a Drama Series
- 2004: Starred with Heath Ledger, Naomi Watts and Geoffrey Rush in the Australian crime drama "Ned Kelly"
- 2003: Cast as the female lead in the dark comedy "The Hard Word"
- 2002: Portrayed Dennis Quaid's wife in "The Rookie"
- 2001: Cast in the title role of "Very Annie Mary"
- 2001: Portrayed Johnny Depp's hysterical mother in "Blow"
- 2001: First major series role on American Television, playing Brenda Chenowith on the award-winning HBO series "Six Feet Under"; earned Golden Globe (2002) and Emmy (2003) nominations for Best Supporting Actress in a Drama Series
- 1999: Played a single magazine writer who seemingly enters a parallel world where she finds herself married with children in "Me Myself I"
- 1998: Co-starred in "Divorcing Jack," playing a woman who works for a strip-o-gram firm
- 1998: Had one of her best screen roles as flautist Hilary du Pre, the older sister of famed cellist Jacqueline du Pre (played by Emily Watson) in the biopic "Hilary and Jackie"; received an Academy Award nomination for Best Supporting Actress
- 1998: Directed (also produced and wrote) the 14-minute short "Tulip"
- 1997: Had leading role in the British film "My Son the Fanatic"
- 1997: Re-teamed with P.J. Hogan to play a supporting role in "My Best Friend's Wedding"
- 1996: Re-teamed with Collette for the Austrailan film "Cosi"
- 1996: Feaured role as the ill-mannered pig farmer's wife in Michael Winterbottom's "Jude"
- 1994: Breakthrough screen role in P.J. Hogan's "Muriel's Wedding"; co-starred with Toni Collette as best friends and fellow outcasts
- 1993: Played leading role in the Australian TV series, "Secrets"
- 1991: First role in the short film "Barbie Gets Hip"; screened at the Melbourne International Film Festival
- 1991: Joined the Australian theater group Woolly Jumpers




