Family
- father Dick Pfeiffer:
- brother Rick Pfeiffer: Older
- sister DeDee Pfeiffer: Born in 1964; best known for playing Cybill Shepherd's daughter on the series "Cybill" (CBS)
- sister Lori Pfeiffer: Born in 1965
- daughter Claudia Rose Kelley: Biracial; born and adopted by Pfeiffer in 1993; adopted by Kelley following their marriage
- son John Henry Kelley: Born Aug. 5, 1994; father, David E Kelley
- mother Donna Pfeiffer:
Companions
- Fisher Stevens: together for three years c. 1989-91
- Val Kilmer: dated in the 1980s; dedicated poems to her in his privately published "My Eden After Burns"
