Family
- father Richard Cusack: Owner of film production company; appeared in "The Fugitive" (1993); died June 2, 2003
- mother Nancy Cusack:
- sister Ann Cusack: Born May 22, 1961; appeared in "Grosse Point Blank" (1997)
- sister Joan Cusack: Born Oct. 11, 1962; appeared together in "Say Anything" (1989), "Grosse Pointe Blank" (1997), High Fidelity (2000) and Martian Child (2007)
- brother Bill Cusack: Born c. 1964; appeared in "Ed Wood" (1994)
- sister Susie Cusack: Born c. 1971
Companions
- Companion Jodi Lyn O'Keefe: Dated in 2003
- Alison Eastwood: dated in 1997
- Claire Forlani: dated c. 1997-98
- Corina Katt: reportedly dated in 1998; she claims they were "just friends"
- Minnie Driver:
- Neve Campbell: reportedly dating as of late fall 1998; no longer dating as of December 2002
