Family
- mother Muriel Isabel:
- sisters : Has five; Dafoe was the seventh of eight children
- brothers : Has two; Dafoe was the seventh of eight children
- father William Dafoe:
- son Jack Dafoe: Born c. 1982; mother, Elizabeth LeCompte
Companions
- Elizabeth LeCompte: born c. 1945; member and director of the Wooster Group; awarded a MacArthur grant in 1995 for $310,000
- wife Giada Colagrande: Co-wrote and co-starred together in "Widow's Lover" that premiered at the 2005 Venice Film Festival; began dating in 2004; married March 25, 2005
