Family
- great-grandmother : Full-blooded Native American; died at the age of 102
- father John Christopher Depp: Divorced Depp's mother when he was 15 (c. 1978)
- mother Betty Sue Palmer: Depp has a tattoo with his mother's name on his left arm; divorced Depp's father when he was 15 (c. 1978)
- sister Christie Dembrowski: Born c. 1961; handles Depp's affairs from her Florida home
- sister Debbie Depp: Older
- brother Daniel Depp: Older
- daughter Lily-Rose Melody Depp: Born May 27, 1999; mother, Vanessa Paradis
- son Jack Depp: Born April 9, 2002; mother Vanessa Paradis
Companions
- Companion Jennifer Grey: Dated from 1988-1989; were briefly engaged, before they split
- Companion Vanessa Paradis: French; born c. 1972; together from June 1998; mother of Depp's two children
- Companion Kate Moss: Born Jan. 16, 1974; together from 1994-1998; announced engagement in 1995; separated in 1997; reunited briefly; split in May 1998
- Jennifer Grey: engaged; no longer together
- Kate Moss: born on Janauary 16, 1974; had announced engagement in 1995; separated in 1997; reunited briefly; permanently separated in May 1998
- Sherilyn Fenn: no longer together
- Vanessa Paradis: French; born c. 1972; together from June 1998; mother of Depp's daughter
- Winona Ryder: together from 1990 to 1993; announced engagement; Depp had a tattoo of 'Winona Forever' on his arm, which he has altered to say the more appropriate 'Wino Forever': "It's no coincidence that I ended up in France. I have a deep appreciation of the grape"
