- 2009: Will star in the upcoming Broadway revivals of Neil Simon’s autobiographical plays "Brighton Beach Memoirs" and "Broadway Bound"
- 2008: Cast opposite Nathan Lane in the Broadway production of David Mamet's "November"; received a Tony award nomination for Featured Actress in a Play
- 2007: Cast in the Garry Marshall-directed dark comedy "Georgia Rule"
- 2006: Co-starred in the comedy, "Artie Lange's Beer League"
- 2006: Guest starred on ABC's "Desperate Housewives" as meddling neighbor Carolyn Bigsby; earned an Emmy nomination for Outstanding Guest Actress in a Comedy Series
- 2006: Earned an Emmy nomination for Best Guest Actress in a Comedy Series for "Monk"
- 2001: Replaced Julie Walters in the London stage production of "All My Sons"
- 2000: Starred in the L.A. premiere of "Looking for Normal"
- 2000: Cast as a psychiatrist in Mike Figgis' experimental "Time Code"; not seen in theatrically released version; replaced by Glenne Headley; will be included on the DVD release
- 1999: Starred opposite Norm Macdonald in ABC's "Norm/The Norm Show"
- 1997: Had pivotal role in "Scream 2"
- 1995: Broadway debut, "My Thing of Love"
- 1988: Played the title character's younger sister, Jackie on the ABC sitcom "Roseanne"; earned Emmy (1995) and Golden Globe (1993, 1995) nominations for Best Supporting Actress
- 1985: Feature film debut, "Desperately Seeking Susan"
- 1985: TV movie debut, "The Execution of Raymond Graham"
- 1984: Went to New York with Steppenwolf production of "Balm in Gilead"
- 1981: Cast member of TV series, "Saturday Night Live"
- 1976: Original member of Steppenwolf Theatre Company in Chicago
- Raised in Edwardsville, Illinois




