Family
- great-aunt Zoe Akins: Pulitzer Prize-winning playwright
- father : Financial controller at Southern Illinois University
- mother :
- daughter Zoe Perry: Born c. 1984; father, Jeff Perry; named after Metcalf's great-aunt, Zoe Atkins
- son Will Theron Roth: Born Nov. 20, 1993; father, Matt Roth
- daughter Mae Akins Roth: Born July 3, 2005; father, Matt Roth
Companions
- husband Matt Roth: appeared as Metcalf's boyfriend on the series "Roseanne"; have one child together
- Terry Kinney: met in college
