- 2009: Began tour of "John Leguizamo Live!" at the Long Wharf Theatre in New Haven, CT
- 2009: Again voiced Sid the sloth in the animated sequel "Ice Age: Dawn of the Dinosaurs"
- 2008: Co-starred in M. Night Shyamalan's "The Happening"
- 2008: Joined a Broadway revival of David Mamet's "American Buffalo"
- 2007: Had a supporting role in the Mike Newell adaptation of Gabriel Garcia Marquez's "Love in the Time of Cholera"
- 2007: Cast in the Spike TV eight part series, "The Kill Point"
- 2006: Published memoir, Pimps, Hos, Playa Hatas and All the Rest of My Hollywood Friends: My Life
- 2005: Joined the cast of the NBC medical drama "ER" playing Dr. Victor Clemente
- 2005: Cast in George A. Romero's "Land of the Dead," a thriller where the living dead have taken over the world
- 2003: Co-starred in "Spun"; premiered at Cinevegas Film Festival
- 2002: Voiced Sid the sloth for the animated feature "Ice Age"
- 2002: Made directorial debut with HBO production "Infamous"; also starred as a boxer who escapes his impoverished roots through fame
- 2001: Appeared on stage in one-person show "John Leguizamo LIVE"; opened on Broadway as "Sexaholix"; also aired on HBO
- 2001: Executive produced "Pinero," a biopic of the poet-playwright Miguel Pinero
- 2001: Cast as Toulouse-Lautrec in Baz Luhrmann's big screen musical "Moulin Rouge!"
- 1999: Executive produced "Joe the King," written and directed by Frank Whaley; also had a small role in film
- 1999: Co-starred in Spike Lee's "Summer of Sam"
- 1998: Starred in HBO adaptation of "Freak," directed by Spike Lee; garnered Emmy Award for performance
- 1997: Premiered one-person show, "Freak: A Semi-Demi-Quasi-Autobiographical Comedy"; opened on Broadway in 1998; received Tony Award nominations for Best Play and Best Actor
- 1997: Co-produced "The Pest" with writing partner Katz, revisiting a variety of characters he had created in the past
- 1996: Formed Lower East Side Prods. (with screenwriter David Bar Katz); also signed two-year, first-look deal with New Line Cinema
- 1996: Portrayed Tybalt, a macho Latin gangster in Baz Lurhmann's "William Shakespeare's Romeo and Juliet"
- 1995: Breakthrough lead performance as a touchingly funny transvestite in "To Wong Foo, Thanks for Everything, Julie Newmar"
- 1995: Created (also wrote and starred) "House of Buggin'" (FOX), a Latino-oriented sketch comedy show
- 1993: Portrayed Benny Blanco 'from the Bronx' in De Palma's "Carlito's Way"
- 1993: Starred in "Super Mario Bros.," as Luigi Mario opposite Bob Hoskins
- 1992: Created the one-man show, "Spic-o-Rama: A Dysfunctional Comedy"; later taped and broadcast as an installment of the "HBO Comedy Hour"
- 1991: Played the thug who shoots Harrison Ford in "Regarding Henry"
- 1991: Appeared in "Hangin' With the Homeboys," directed by Joseph Vasquez
- 1989: Wrote and starred in the one-man show, "Mambo Mouth"; later taped and broadcast as an installment of the "HBO Comedy Hour"
- 1989: First notable film credit, Brian De Palma's "Casualties of War"
- 1989: Appeared in stage production, "Parting Gestures," with the Intar Hispanic American Arts Center
- 1985: First substantial film role, "Gentile Alouette," a Chilean-French co-production starring Geraldine Chaplin (shelved until 1990)
- 1984: Feature acting debut, in Paul Morrissey's "Mixed Blood," a French-produced crime comedy shot on NYC's Lower East Side
- 1984: Played the recurring role of vengeful drug boss Orlando Calderone in three episodes of "Miami Vice" (NBC)
- 1969: Moved to New York from Colombia with family at age four
- Grew up in Jackson Heights, Queens
- Moved to Colombia and back to New York twice with younger brother before age nine
- Began writing comedy material in high school, trying it out on classmates
- Played NYC comedy clubs in mid-1980s; worked also as comedy duo with Carolyn McDermott
- While attending NYU, discovered by casting director Bonnie Timmerman who saw him in the award-winning student film "Five Out of Six"
- Arrested while in high school for truancy and then for commandeering the public address system of a subway train with a friend
- Was a member of the New York improvisational performance group First Amendment




