Family
- father Alberto Leguizamo: Divorced from Leguizamo's mother in 1978; Puerto Rican immigrant
- mother Luz Leguizamo: Divorced from Leguizamo's father in 1978; Colombian immigrant
- brother Sergio Leguizamo: Younger
- daughter Allegra Sky Leguizamo: Born Oct. 23, 1999; mother, Justine Maurer
- son Ryder Lee Leguizamo: Born Dec. 5, 2000; mother Justine Maurer
Companions
- Carolyn McDermott: met in 1986
- Justine Maurer: dating from 1997
- Samantha Mathis: co-starred in "Super Mario Bros"
