- 2008: Appeared in the Broadway play, "Top Girls"; received a Tony award nomination for Featured Actress in a Play
- 2006: Cast in the play "The Coast of Utopia," a trilogy by Tom Stoppard; earned a Tony award nomination
- 2004: Guest-starred on an episode of "7th Heaven" (WB); also received her first writing credit for a different episode that year entitled "Red Socks"
- 2002: Nominated for an Emmy Award for her guest appearance on the television drama "Law & Order: Special Victims Unit" (NBC)
- 2001: Starred in a Chicago stage production of "Hedda Gabler"
- 2001: Made stage directorial debut with "Absolution," performed at Chicago's Steppenwolf Theatre Company
- 1999: Had a recurring role in the television drama "ER" (NBC) as Meg Corwyn
- 1999: Appeared in the ensemble film "200 Cigarettes"
- 1998: Donned a dark wig to play Edward Furlong's sister in John Waters' "Pecker"
- 1997: Won praise for leading role in "Eye of God"
- 1997: Appeared in "The Defenders: Payback", the first of a projected series of TV-movies for Showtime
- 1996: Portrayed the lesbian lover of radical feminist Valerie Solanas in the indie film "I Shot Andy Warhol"
- 1992: First feature starring role, "Samantha"
- 1991: Co-starred with Campbell Scott in Shakespeare's "Pericles, Prince of Tyre" at the Public Theater
- 1989: Played the indignant teenage daughter of Dianne Wiest in "Parenthood"
- 1988: Second film with River Phoenix, the Academy Award-nominated film, "Running on Empty"
- 1987: Co-starred in the critically praised but commercially unsuccessful feature, "Shy People"
- 1986: Critically lauded performance as the Reverend Spellgood's daughter in "The Mosquito Coast" starring Harrison Ford and her future real-life love interest, River Phoenix
- 1985: First substantial film role, "The River Rat"
- 1985: Breakthrough performance as Stef Steinbrenner in "The Goonies"
- 1983: TV acting debut, "The Hand-Me-Down Kid"
- 1982: Appeared in a Calvin Klein jeans commercial at age 11
- 1981: Made film acting debut in a bit part in "Rollover"
- 1979: Stage debut at age eight in "The Haggadah" at New York Public Theater
- Formed a production company called, Everything is Horrible; produced a number of short films for the internet




