- 2009: Re-teamed with Woody Allen for his New York–based comedy "Whatever Works"
- 2008: Featured in Woody Allen's "Vicky Cristina Barcelona" with Javier Bardem and Penélope Cruz
- 2007: Co-starred with Ryan Gosling in the indie film, "Lars and the Real Girl"
- 2006: Played Stark's (Sean Penn) press secretary in Steven Zaillian's big-screen adaptation of "All the King's Men"
- 2005: Starred in the George Clooney-directed “Goodnight, and Good Luck”
- 2004: Co-starred in Lars von Trier's "Dogville"
- 2004: Played the wife the 1980 USA Olympic hockey coach in "Miracle"
- 2003: Portrayed Katie Holmes' cancer stricken mother in "Pieces of April"; earned Golden Globe, Independent Spirit Award, SAG and Academy Award nominations for Best Actress in a Supporting Role
- 2003: Co-starred with Peter Dinklage in "The Station Agent"; earned a SAG nomination for Best Actress
- 2002: Played Julianne Moore's best friend Eleanor in Todd Hayne's "Far From Heaven"
- 2002: Had a recurring role as Ruth's (Frances Conroy) sister, Sarah in the HBO drama "Six Feet Under"
- 2002: Appeared in the heist film "Welcome to Collinwood"
- 2001: Had featured role in "Wendingo"; screened at Sundance
- 2001: Co-starred with Jack Nicholson in "The Pledge" as the religious mother of a murder victim
- 1999: Played the prison warden's wife in "The Green Mile"; adapted from a Stephen King's novel
- 1998: Received strong notices for playing a washed-up, drug addicted German actress in "High Art"
- 1998: Appeared in the ensemble feature "Playing By Heart"
- 1995: Cast as regular on ABC drama series "Murder One"
- 1991: TV series debut as regular on "Davis Rules" (ABC); only appeared during the show's first season
- 1990: TV-movie debut in "Ernest Hemingway's The Old Man and the Sea" (NBC)
- 1987: Film debut as Mrs Elliot Ness in "The Untouchables"
- 1986: Broadway debut in revival of John Guare's "House of Blue Leaves"
- 1985: TV debut on an episode of the ABC drama "Spenser: For Hire"
- Appeared in over 30 stage productions


