- 2008: Executive produced (with husband Tom Hanks) the film adaptation of the West End stage musical, "Mamma Mia!"
- 2006: Performed the role of Roxie Hart in the Broadway revival of "Chicago"
- 2005: Co-starred in Arie Posin's darkly satiric feature "The Chumscrubber"
- 2003: Produced the short-lived CBS series "My Big Fat Greek Life"; also starring Nia Vardalos
- 2002: Played Bob Crane's wife (Greg Kinnear) in "Autofocus"
- 2002: Co-produced (with Hanks) Nia Vardalos's feature adaptation "My Big Fat Greek Wedding"; was the driving force behind the film, which became the highest-grossing independent film of all time
- 2000: Acted in the LA premiere of the Pulitzer-winning "Dinner With Friends"
- 1999: Cast as Richard Gere's ex-wife in "Runaway Bride"
- 1999: Withdrew from the cast of Neil Simon's play "The Dinner Party" due to 'creative differences'
- 1998: Played Susan Borman, wife of astronaut Frank Borman, in the HBO miniseries "From the Earth to the Moon"; husband Tom Hanks directed, produced and scripted
- 1996: Cast opposite Arnold Schwarzenegger in the comedy "Jingle All the Way"
- 1995: Co-starred with Rosie O'Donnell, Melanie Griffith and Demi Moore in the coming of age drama "Now and Then"
- 1994: Again teamed with Ephron for "Mixed Nuts"
- 1993: Cast opposite real life husband Tom Hanks in Nora Ephron's "Sleepless in Seattle"
- 1990: Cast as a PR woman in "The Bonfire of the Vanities"
- 1985: First starring role in a feature, "Volunteers"; cast opposite future husband Tom Hanks
- 1982: First recurring role on a TV series, playing Nurse Lacey on "M*A*S*H" (CBS)
- 1982: Made guest appearances on two episodes of ABC's "Happy Days" (billed as Margarita Ibrahimoff)
- 1980: Feature film debut, "Cheech & Chong's Next Movie"
- 1980: Guest starred on future husband's sitcom, "Bosom Buddies" (ABC)
- 1978: TV-movie debut, "Flying High"
- Raised in Los Angeles
- Appeared in numerous stage productions at the Macowan Theater in London
- Began modeling at age 14, after being discovered by a fashion photographer




