- 2008: Joined an ensemble cast for the comedy "How to Lose Friends & Alienate People"
- 2008: Reprised role of Agent Scully for "The X-Files: I Want to Believe" the second feature based on the popular series
- 2006: Featured in "A Cock and Bull Story" a film version of the novel, Tristram Shandy
- 2006: Played the wife to an English doctor in "The Last King of Scotland" about Ugandan dictator Idi Amin (Forest Whitaker)
- 2005: Portrayed Lady Dedlock in the BBC/PBS adaptation of "Bleak House"; based on the novel by Charles Dickens; earned BAFTA (2006), Emmy (2006) and Golden Globe (2007) nominations for Best Actress in a Miniseries or Television Movie
- 2000: Starred as Lily Bart in Terence Davies film adaptation of "The House of Mirth"
- 1998: Reprised Emmy-winning role of Scully for the feature film "The X-Files"
- 1998: Had supporting role as an eccentric, alcoholic biker chick in "The Mighty"
- 1998: Offered fine turn as a romantically embittered theater director finding love with architect Jon Stewart in the ensemble film "Playing By Heart"
- 1997: Made cameo appearance as a big-haired working-class girl who fights with her boyfriend in "Chicago Cab"
- 1993: Played FBI agent Dana Scully on the FOX paranormal crime drama series, "The X-Files"
- 1992: Feature film debut in "The Turning"
- 1991: Appeared in the Off-Broadway production "Absent Friends"
- Moved from London, England to Grand Rapids, Michigan at age 11
- Performed the book tape version of Anne Rice's "Exit to Eden"
- Cast in the pilot episode of "The X-Files" the same day her last unemployment check arrived
- Got involved in community theater productions while still in high school




