Family
- mother Bettine Close:
- grandfather Edward Close Sr: Was director of the American Hospital
- father William T Close: Traveled to the Congo on author behest of Moral Re-Armament group to run medical clinics when Glenn was 13; he stayed after the coup d'etat and became chief doctor for the Congolese army in the newly formed Zaire, Africa; also served as a personal physician to President Mobutu Sese Seko
- sister Tina Close: Older
- brother Sandy Close: Younger
- sister Jessie Close: Co-owns with Glenn Close, a 1960s-themed coffee shop, Leaf and Bean, and a neighboring bookstore called Poor Richards near Bozeman, Montana
- daughter Annie Maude Starke: Born April 26, 1988; father, John Starke
Companions
- Cam Neely: a hockey player with the Boston Bruins; no longer together
- John Starke: had production company Trillium Productions with Close; separated in 1991; father of her daughter Annie
- Kevin Kline: dated in the 1970s
- Len Cariou: lived together in the 1970s
- Robert Pastorelli: met in 1999; Close maintains they are not romantically involved
- Stephen Beers: engaged to be married as of March 1995; separated in 1999
- William Hurt: had brief relationship
- Woody Harrelson: five-month relationship ended in September 1991
- husband David Shaw: Married Feb. 3, 2006 in a small, private ceremony in Maine
