Family
- father Charles Harmon: Separated from Moore's mother after a two-month marriage in 1962 during which she was conceived; divorced from Moore's mother; later re-married
- step-father Danny Guynes: Born in 1943; adopted Moore when he married her mother; sold newspaper advertisements; moved frequently; was reportedly an alcoholic who would become abusive when drunk; commited suicide in October 1980
- mother Virginia Guynes: Born in 1943; died of a brain tumor at age 54 on July 2, 1998; Moore had been estranged from her mother for several years but had reconciled with her when she was diagnosed with her terminal illness
- half-brother Morgan Guynes: Born in 1967; son of Virginia and Danny Guynes
- half-brother James Craig Harmon: Younger
- daughter Rumer Glenn Willis: Born Aug. 16, 1988; father Bruce Willis; named after British novelist Rumer Godden; made feature film debut in "Striptease" (1996) playing Moore's daughter
- daughter Scout LaRue Willis: Born July 20, 1991; father Bruce Willis; first name is after the child narrator of the novel To Kill a Mockingbird
- daughter Tallulah Belle Willis: Born Feb. 3, 1994; father Bruce Willis; appeared as baby Pearl in "The Scarlet Letter" (1995)
Companions
- husband Bruce Willis: Second husband; met in August 1987; married in a small ceremony in Las Vegas and then again with friends and family on Nov. 21, 1987 by singer-minister Little Richard; announced split in June 1998; divorced in October 2000
- Companion Emilio Estevez: Met in 1984, while filming St. Elmo's Fire (1985); had three-year engagement that ended in 1987
- husband Ashton Kutcher: Third husband; began dating in May 2003; married Sep. 24, 2005; Kutcher is 16 years younger than Moore
- Companion Guy Oseary: Madonna's business partner; dated briefly in 2002
- husband Freddy Moore: First husband; married from 1980-1984; Demi kept the last name Moore
- Companion John Stamos: Dated when they both appeared on "General Hospital" (ABC) in the early 1980s
- husband Bruce Willis: second husband; met in August 1987; married in a small ceremony in Las Vegas and then again with friends and family on November 21, 1987 by singer-minister Little Richard; announced separation in June 1998; divorced in October 2000
- Emilio Estevez: became a couple in 1984; had three-year engagement that ended in 1987
- husband Freddy Moore: married in 1980; separated; divorced in 1984
- Guy Oseary: dating as of October 2002
- John Stamos: dated when they both appeared on "General Hospital" in the early 1980s
- Oliver Whitcomb: born c. 1970; reportedly dating as of 1999
- Companion Oliver Whitcomb: Born c. 1970; eight years younger than Moore; began dating in 1999; no longer together
