Family
- daughter Josephine Demme: Mother, Joanne Howard
- brother Peter Demme:
- brother Rick Demme:
- father : Was the PR director for the Fontainebleu Hotel in Miami in the 1960s
- mother Dorothy Demme: Appeared in bit roles in several of her son's films; died Nov. 20, 1995 of emphysema at age 81
- cousin Robert Castle: Was the subject of Demme's 1992 feature documentary "Cousin Bobby"; minister at St. Mary's Episcopal Church in Harlem, NYC and a believer in liberation theology; had lost touch with Demme for over 30 years before reuniting with him in 1989 to work on the film
- nephew Ted Demme: Best known for directing "The Ref" (1994) and "Blow" (2001); died of a heart attack in 2002 at age 38
- niece Jennifer Demme: Worked for MTV
- daughter Ramona Castle Demme: Born c. 1987; mother, Joanne Howard
- son Brooklyn James Demme: Born c. 1989; mother, Joanne Howard
