Family
- grandfather Walter Huston: Born in 1884; played leading roles in many important American films of the 1930s and 40s; directed by his son John in his Oscar-winning role in "The Treasure of the Sierra Madre" (1948); died from an aortic aneurysm in 1950
- father John Huston: Born in 1906; worked in Hollywood as a screenwriter before directing "The Maltese Falcon" (1941); earned Oscars for directing and scripting "The Treasure of Sierra Madre" (1948); directed daughter Anjelica in her Oscar-winning performance in "Prizzi's Honor" (1985); died from emphysema in 1987
- mother Enrica Soma: Born in 1930; married to Huston from 1950 until her death in 1969 at age 39 from an auto accident; they lived apart from 1962 until her death; also had child, Allegra, from a different relationship, who Huston raised as his daughter
- brother Tony Huston: Born in 1950; mother, Enrica Soma; wrote screenplay for "The Dead" (1987), directed by father and starring sister Anjelica; married to actress Pat Delaney
- half-brother Danny Huston: Born in 1962; mother, Zoe Sallis; formerly married to Virginia Madsen; directed "Mr. North" (1987), John Huston's final film (as executive producer and co-screenwriter), which also starred his sister, Anjelica
- half-sister Allegra Huston: Born in 1963; mother, Enrica Soma; father was a titled Englishman; adopted by John Huston and raised by him after his wife's tragic death
Companions
- Bob Richardson: met on a fashion shoot when Huston was still in her teens; according to Richardson, maintained a relationship until the early 1980s
- Jack Nicholson: together from c. 1973; lived together until c. 1983 when she moved out and bought a place nearby; relationship continued until c. 1989 when she learned Nicholson was having a child with another woman
