- 2008: Portrayed a grown Diana in Vadim Perelman's "The Life Before Her Eyes"
- 2006: Played a superhero who gets revenge on the boyfriend that dumped her in Ivan Reitman's "My Super Ex-Girlfriend"
- 2005: Chosen as the new face of Louis Vuitton, for their Spring 2005 campaign
- 2005: Played a woman in her late thirties romancing a younger man in Ben Younger's "Prime" opposite Meryl Streep
- 2005: Re-teamed with her "Pulp Fiction" castmate, John Travolta in "Be Cool"
- 2005: Starred as Swedish secretary Ulla, in the movie-musical version of "The Producers"
- 2003: Re-teamed with Tarantino to portray a female assassin who awakens from a four-year coma and seeks revenge on her former boss; film released in two Volumes "Kill Bill Vol. 1" (2003) and "Kill Bill Vol. 2" (2004); received Golden Globe nominations for Best Actress for Vol. 1 (2003) and Vol. 2 (2004)
- 2003: Played the love interest to Ben Affleck's character in the thriller "Paycheck"
- 2002: Had featured role in the Ethan Hawke-directed "Chelsea Walls" (filmed in 1999)
- 2002: Co-starred (also executive produced) with Juliette Lewis in the HBO produced, "Hysterical Blindness"; film first screened at Sundance; received a SAG nomination for Best Actress in a TV movie
- 2001: Co-starred with husband Ethan Hawke and Robert Sean Leonard in the Richard Linklater directed "Tape"; received an Independent Spirit Award nomination for Best Lead Actress
- 1999: Played the second wife of a jazz musician (Sean Penn) in Woody Allen's "Sweet and Lowdown"
- 1998: Cast as Emma Peel opposite Ralph Fiennes' John Steed in the feature version of "The Avengers"
- 1998: Played Fantine in Bille August's remake of "Les Miserables"
- 1997: Starred opposite future husband Ethan Hawke in the futuristic thriller "Gattaca"
- 1997: Delivered a scene-stealing turn as the villainous Poison Ivy in "Batman & Robin"
- 1996: Offered a fine comic turn as a ditzy model in "The Truth About Cats and Dogs"
- 1994: Had leading role of Sissy Hankshaw in the ill-fated film version of "Even Cowgirls Get the Blues"
- 1994: Earned a Best Supporting Actress Oscar nomination playing a gangster's wife in Quentin Tarantino's "Pulp Fiction"
- 1992: TV-movie debut in "Robin Hood" (Fox)
- 1990: Starred as the wife of writer Henry Miller in "Henry & June"; first film to receive the NC-17 rating
- 1989: Played Venus in "The Adventures of Baron Munchausen"
- 1988: First gained acclaim with her role as the virginal Cecile in "Dangerous Liaisons"
- 1987: Film debut in "Kiss Daddy Goodnight"
- 1986: Moved to Manhattan to attend the Professional Children's School
- Will co-star with Colin Firth and Jeffrey Dean Morgan in the romantic comedy "The Accidental Husband"
- Raised in Amherst, Massachusetts
- Lived in a artists' colony in Woodstock, New York




