- 2009: Portrayed 'Ivan the Terrible' in "Night at the Museum: Battle of the Smithsonian"
- 2006: Co-wrote, directed and co-starred in Academy Awards parody, "For Your Consideration"
- 2003: Co-Wrote (with Eugene Levy), directed and co-starred in "A Mighty Wind"; earned an Independent Spirit Award nomination for his screenplay
- 2001: Wrote, directed and starred in the dog show-themed comedy, "Best in Show"
- 1998: Directed the comedy "Almost Heroes"
- 1997: Wrote, directed and starred in the cult hit "Waiting for Guffman"
- 1993: Directed Daryl Hannah in the title role of "Attack of the 50 Ft. Woman" (HBO)
- 1992: Again collaborated with Rob Reiner for "A Few Good Men"
- 1991: Executive produced the CBS sitcom "Morton and Hayes"; also directed premiere episode
- 1989: Made directorial debut with the Hollywood satire, "The Big Picture"; also co-wrote
- 1988: Co-starred with Mayron in "Sticky Fingers"
- 1987: Re-teamed with Reiner for "The Princess Bride"
- 1984: Had breakthrough role as guitarist Nigel Hufnel in Rob Reiner's mockumentary, "This Is Spinal Tap"; and co-wrote
- 1984: Hired on NBC's "Saturday Night Live" for one year only
- 1981: Re-teamed with Melanie Mayron in "Heartbeeps"
- 1980: Appeared with his brother Nicholas in Walter Hill's western, "The Long Riders"
- 1979: Played Jeb Stuart Magruder in the CBS miniseries, "Blind Ambition"
- 1978: First romantic lead opposite Melanie Mayron in "Girlfriends"
- 1977: Made TV episodic debut on "All in the Family" (CBS)
- 1977: TV-movie debut, "Billion Dollar Bubble" (NBC)
- 1975: Co-wrote and performed in "The Lily Tomlin Special" (ABC)
- 1975: Regular player on the ABC variety series, "Saturday Night With Howard Cosell"
- 1973: Was a member of the ensemble "National Lampoon's Lemmings" at the Village Gate Theatre in NYC
- 1972: Cast as Norman in Michael Weller's "Moonchildren" on Broadway
- 1971: Feature film debut playing a resident in "The Hospital"
- 1970: Broadway debut, "Room Service"
- 1969: Made Off-Broadway debut in "Little Murders"
- 1967: First collaboration with Michael McKean, playing in a band in New York
- 1966: Began acting at New Haven's Long Wharf Theater




