- 2008: Directed and co-starred with Renée Zellweger in the 1920s-era football comedy, "Leatherheads"
- 2008: Joined an ensemble cast for the Coen's brothers' "Burn After Reading"
- 2007: Played the title role in "Michael Clayton," written and directed by Tony Gilroy; also co-produced; earned Golden Globe, SAG and Oscar nominations for Best Actor in a Motion Picture Drama
- 2007: Reprised role of Danny Ocean for "Ocean's 13"
- 2006: Formed Smoke House production company with Grant Heslov and signed a three-year first-look production and development deal with Warner Bros. Pictures and Warner Bros. Television
- 2006: Co-starred with Cate Blanchett in "The Good German," about an American journalist trying to solve a murder mystery in post-war Berlin; directed by Steven Soderbergh
- 2005: Directed, co-wrote and portrayed producer Fred Friendly in "Goodnight, and Good Luck," the 1950s-era drama about legendary TV newsman Edward R. Murrow; earned an Independent Spirit Award nomination for Best Director; received Oscar and Golden Globe nominations for Directing and Screenplay; was also nominated by the Directors Guild of America
- 2005: Produced and starred in "Syriana," a geopolitical thriller based on the real-life memoirs of CIA agent Robert Baer; earned a SAG nomination for Supporting Actor
- 2004: Returned with the original cast for "Ocean's Twelve" directed by Steven Soderbergh
- 2002: Had small but memorable role as a crippled crook in "Welcome to Collinwood," a farcical comedy screened at Cannes
- 2002: Feature directorial debut, "Confessions of a Dangerous Mind"; also had supporting role
- 2002: Starred in the sci-fi thriller feature "Solaris," directed by Soderberg
- 2002: Cast as a divorce attorney in the Coen brothers' feature "Intolerable Cruelty"
- 2001: Reteamed with Soderbergh for remake of "Ocean's Eleven"; made through production company Section Eight
- 2001: With Soderbergh, served as producer of Marc Rocco's "The Jacket"
- 2000: Co-starred in the Coen brothers' "O Brother, Where Art Thou?"
- 2000: Executive produced and acted in the live, two-hour broadcast of "Fail Safe" (CBS), adapted from the Cold War novel by Harvey Wheeler and Eugene Burdick; directed by Stephen Frears; project reteamed him with "ER" co-star Noah Wyle
- 2000: With Wahlberg, co-starred in the film version of Wolfgang Petersen's "The Perfect Storm"
- 1999: Wrote and executive produced the HBO comedy series pilot "Kilroy"
- 1999: Teamed with Ice Cube and Mark Wahlberg in David O Russell's critically-acclaimed "Three Kings"
- 1999: Contributed the voice of Dr Gouache to the feature "South Park: Bigger, Longer & Uncut"
- 1998: Signed separate two-year development deals with CBS and Warner Bros.
- 1998: Played an escaped prisoner in Steven Soderbergh's "Out of Sight"
- 1997: Portrayed Batman/Bruce Wayne in "Batman & Robin," the fourth installment in the series, directed by Joel Schumacher
- 1997: Provided the voice of Sparky the dog on an episode of the Comedy Central animated series "South Park"
- 1996: Played romantic lead opposite Michelle Pfeiffer in "One Fine Day"
- 1996: Co-starred with Quentin Tarantino in the vampire horror flick "From Dusk Till Dawn"
- 1996: Formed Maysville Pictures (formerly Left Bank Productions), named for the Kentucky town in which he grew up
- 1994: Cast as pediatrician, Dr. Doug Ross on the hit NBC medical drama "ER"; reprised role for one episode in the final season (2009)
- 1993: Played Falconer, a married policeman who becomes involved with Teddy Reed (Sela Ward), on "Sisters" (NBC)
- 1991: Appeared on the ABC sitcom "Baby Talk"; quit in frustration over "creative differences" with the producers
- 1991: Declined Quentin Tarantino's request to read for a role in "Reservoir Dogs"
- 1990: Cast in the short-lived detective series "Sunset Beat" (ABC); show cancelled after three episodes
- 1988: Played the recurring role of Booker, the male chauvinist boss on the first season of "Roseanne" (ABC)
- 1988: Had starring role in the horror spoof "The Return of the Killer Tomatoes"
- 1987: Played role of Tom Bennett in failed NBC comedy pilot "Bennett Brothers"
- 1987: Played a drug dealer in the play "Vicious" at the Steppenwolf Theatre in Chicago
- 1986: TV-movie debut, "Combat High" (NBC)
- 1985: Had a recurring role as carpenter George Burnett on the "The Facts of Life" (NBC)
- 1984: Debut as TV series regular in the CBS sitcom "E/R" playing a young orderly named Ace
- 1982: Appeared as an extra in "... And They're Off," a film starring his cousin Miguel Ferrer
- 1982: Moved to Los Angeles at age 21; lived with his aunt, Rosemary Clooney, working as her handyman and chauffeur
- 1977: Tried out for Cincinnati Reds baseball team at age 16
- 1975: Suffered for a year with Bell's palsy
- 1974: Served as a floor manager on his father's locally produced TV show
- Beginning at age five, assisted on father's local Cincinnati talk show, "The Nick Clooney Show"
- Received first professional job, a stereo commercial, by appearing at the audition with a six-pack
- With Soderbergh, formed Section Eight, a production company
- Feature acting debut in the unreleased "Grizzly II - The Predator" (Note: some sources say this was filmed in 1982 while others say 1984)
- Raised in rural Kentucky and Ohio
- Worked cutting tobacco to earn enough money to buy a car in order to drive cross-county




