Family
- father Nick Clooney:
- mother Nina Bruce Clooney: Met husband when she was crowned first runner up at Miss Kentucky pageant and he was emcee
- aunt Rosemary Clooney: Appeared on two episodes during the first season of NBC's "ER" as an Alzheimer's patient prone to belting out songs; formerly married to actor Jose Ferrer with whom she had five children; died on June 29, 2002 of lung cancer
- sister Ada Zeidler: Born c. 1959; married with two children
- cousin Miguel Ferrer: Born Feb. 7, 1955; son of Jose Ferrer and Rosemary Clooney
Companions
- Companion Krista Allen: Reportedly dated during filming of "Confessions of a Dangerous Mind" (2002); began seeing eachother again in 2003; split March 2004
- Companion Maria Bertrand: Canadian; briefly dated in 2002; no longer together
- Companion Lisa Snowdon: Dated in 2001 and again in 2004, while he was filming "Ocean's Twelve" (2004); no longer together
- Brooke Langton: reportedly dating as of fall 1999
- Celine Balitran: born c. 1973; French; former law student; dated from 1996 to 1999; met at the trendy Paris nightclub Barfly where she was waitressing while he was filming "The Peacemaker" (1997)
- DeDee Pfeiffer:
- Denise Crosby:
- Jennifer Siebel: dated as of August 2002
- Kelly Preston: together from 1987-89; later married actor John Travolta
- Kimberly Russell: together briefly in mid-1995
- Krista Allen: reportedly dated during filming of "Confessions of a Dangerous Mind"
- Lisa Snowden: dated in 2001
- Maria Betrand: Canadian; born c. 1974; reportedly dating as of spring 2002
- Renee Zellweger: reportedly dated in fall 2001
- Trayler Howard: reportedly dated as of spring 2000
- Companion Traylor Howard: Reportedly dated in 2000; no longer together
- Companion Elisabetta Canalis: Italian; began dating in the Summer of 2009
- Companion Sarah Larson: Began dating in 2007; involved in motorcycle accident with Clooney on Sept. 21, 2007, both suffered broken bones; split in May 2008
