- 2008: Joined an ensemble cast for the Coen's brothers' "Burn After Reading"
- 2008: Cast as Reverend Briegleb in Clint Eastwood's "Changeling"
- 2007: Portrayed Unferth in Robert Zemeckis' big-budget film version of "Beowulf"
- 2007: Portrayed Alan Conway in "Colour Me Kubrick," the true story of a man who posed as director Stanley Kubrick
- 2007: Portrayed Austrian artist Gustav Klimt in Raoul Ruiz's "Klimt"
- 2006: Cast as King Galbatorix, a powerful Dragon Rider in "Eragon" a fantasy/adventure movie based on the novel of the same name
- 2006: Cast in Terry Zwigoff's adaptation of Daniel Clowes' comic story "Art School Confidential"
- 2004: Starred as Comandante John Walesa in Manoel de Oliveira's "Um Filme Falado/A Talking Picture"
- 2003: Co-starred in the comedy feature "Johnny English"
- 2003: Had featured role in the A&E miniseries "Napoleon"; received an Emmy nomination for Outstanding Supporting Actor in a Miniseries or a Movie
- 2002: Made feature directorial debut with "Dancer Upstairs," a police thriller based on a novel by Nicholas Shakespeare
- 2001: Served as one of the producers of "Ghost World"
- 2000: Portrayed film director F W Murnau in "Shadow of the Vampire," a fictionalized account of Murnau's filming of "Nosferatu," based on Bram Stoker's "Dracula"; screened at Cannes
- 2000: Acted opposite Gerard Depardieu in a French televison adaptation of "Les Miserables"; English language version aired in USA on Fox Family Channel in 2001
- 1999: Played John Malkovich, a fictionalized version of himself, in the witty and picaresque "Being John Malkovich"
- 1999: Staged "Hysteria" at Chicago's Steppenwolf Theater Company
- 1999: Played Herman J Mankiewicz in HBO's "RKO 281," detailing the clash between Orson Welles and William Randolph Hearst over the production and release of "Citizen Kane"
- 1998: Offered an over-the-top performance as a Russian mobster in "Rounders," scripted by David Levien and Brian Koppelman
- 1998: Formed Mr. Mudd, a production company, with producers Lianne Halfon and Russell Smith
- 1997: Reveled in his scene-chewing role of Cyrus 'The Virus' Grissom in "Con Air"
- 1996: Portrayed the profligate seducer Gilbert Osmond in "The Portrait of a Lady," adapted from the novel by Henry James
- 1994: Appeared as the sinister Kurtz in TNT movie presentation of "Heart of Darkness," directed by Nicolas Roeg
- 1994: Adapted and directed the Steppenwolf production of Don DeLillo's "Libra," starring Laurie Metcalf and Alexis Arquette
- 1993: Received second Best Supporting Actor Oscar nomination as demented assassin Mitch Leary in "In the Line of Fire"
- 1993: Formed Smith-Malkovich Productions with Russell Smith
- 1992: Played Lennie to Sinise's George in remake of "Of Mice and Men," directed by Sinise; had first essayed the role in a Steppenwolf stage production many years earlier
- 1991: Returned to the New York stage as the bombastic war veteran of Shepard's "States of Shock"
- 1990: Teamed with director Bernardo Bertolucci for the vivdly atmospheric (but torturously slow) "The Sheltering Sky"
- 1988: Offered an intriguing turn as the treacherous French aristocrat Valmont in "Dangerous Liaisons," helmed by Stephen Frears; his on-set romance with co-star Michelle Pfieffer led to end of his marriage to Glenne Headly
- 1988: Debut as executive producer of the film "The Accidental Tourist" (did not act in movie)
- 1987: Starred opposite Joan Allen in the Broadway production of "Burn This"
- 1987: Played dual roles of a nerdy scientist and a lookalike android in Susan Seidelman's "Making Mr. Right"
- 1985: First starring role in a feature as journalist Nicholas Gage in Peter Yates' "Eleni"
- 1985: Reprised stage role of Biff in CBS TV adaptation of "Death of a Salesman," starring Hoffman; received Emmy Award
- 1985: Broadway directing debut, "Arms and the Man"; later assumed leading role, replacing Kevin Kline; production also featured then-wife Glenne Headly
- 1984: Broadway debut, "Death of a Salesman," playing Biff to Dustin Hoffman's Willy Loman
- 1984: Starred in TV adaptation of "True West" (aired on PBS' "American Playhouse")
- 1984: Earned Best Supporting Actor Oscar nomination for his turn as a misnthropic blind man in Robert Benton's "Places in the Heart"
- 1984: Made film debut as photojournalist in "The Killing Fields"
- 1982: Off-Broadway debut in Steppenwolf production of "True West," directed by Sinise (who also co-starred)
- 1981: TV-movie debut, "Word of Honor" (CBS)
- 1978: Appeared in production of Sam Shepard's "Curse of the Starving Class" at Chicago's Goodman Theatre
- 1976: Joined Chicago's Steppenwolf Theatre (founded by Gary Sinise in 1974), working on more than 50 of their productions during the years
- Directed and designed sound for the revival of Lanford Wilson's "Balm in Gilead" at the Steppenwolf Theatre in Chicago and subsequently off-Broadway
- Stage directing debut, "The Rear Column," at the North Light Repertory Theatre, Evanston, Illinois




