Family
- daughter Ava Elizabeth Phillippe: Born on Sep. 9, 1999; father, Ryan Phillippe
- father John Witherspoon: Was a lieutenant colonel in the US Army reserves; later became an ear-nose-throat specialist
- mother Betty Witherspoon: Has her Ph.D in pediatric nursing
- brother John Witherspoon, Jr: Older
- son Deacon Phillippe: Born on Oct. 23, 2003; father, Ryan Phillippe
Companions
- Companion Jake Gyllenhaal: Met while co-starring together in the CIA thriller "Rendition" (2007); reportedly dating since March 2007
- Chris O'Donnell: reportedly dated briefly
- Jeremy Sisto: dated after working together in the 1992 TV-movie "Desperate Choices"
- Mark Wahlberg: co-starred in 1996's "Fear"
- Michael Bomboy: Witherspoon's first high school love
