- 2008: Portrayed controversial Florida politician Katherine Harris in the HBO movie "Recount"; earned Emmy and SAG nominations for Best Actress in a TV-Movie
- 2007: Played Molly Shannon's know-it-all sister-in-law in "Year of the Dog"
- 2006: Reteamed with Lynch to star in "Inland Empire"
- 2005: Appeared in the drama "The Prize Winner of Defiance Ohio" opposite Julianne Moore
- 2005: Co-starred in "Happy Endings," a comedic drama about the ups and downs of relationships
- 2004: Co-starred with Mark Ruffalo, Peter Krause and Naomi Watts in "We Don't Live Here Anymore"
- 2002: Cast as a doctor who takes on HMOs in the Showtime movie "Damaged Care"
- 2001: Acted with then boyfriend Billy Bob Thornton in "Daddy and Them"; written and directed by Thornton
- 1999: Played a teacher, opposite Jake Gyllenhaal and Chris Cooper in Joe Johnston's "October Sky"
- 1998: Offered a critically acclaimed performance in Showtime's "The Baby Dance"; produced by Jodie Foster; earned a Golden Globe nomination
- 1997: Received an Emmy nomination for her guest role as a lesbian who coaxes Ellen DeGeneres out of the closet in the famous "Puppy Episode" of the ABC series "Ellen"
- 1996: Portrayed an irresponsible and drug abusing pregnant woman in Alexander Payne's directorial debut "Citizen Ruth"; Diane Ladd makes a cameo appearance, as Dern's mother
- 1996: Acted the part of Vicki Weaver in "Ruby Ridge: An American Tragedy" (CBS)
- 1995: Executive produced (and acted in) Showtime's "Down Came a Blackbird"
- 1994: Directorial debut, "The Gift"; also starred with Diane Ladd and Isabella Rossellini; broadcast as a presentation of Showtime's Directed By series
- 1993: Portrayed a criminologist assisting in the tracking of a pair of escaped convicts in the Clint Eastwood-directed "A Perfect World"
- 1993: Cast as a woman who falls in love with a man who may be a murderer in the Showtime series "Fallen Angels"; received an Emmy nomination
- 1993: Cast as a paleontologist in Steven Spielberg's blockbuster feature, "Jurassic Park"
- 1992: Received an Emmy nomination for her performance as the widow of an Air Force pilot in the HBO film "Afterburn"
- 1991: Starred as pure-hearted nymphomaniac in Martha Coolidge's "Rambling Rose"; earned first Best Actress Academy Award nomination; also earned a Golden Globe nomination
- 1990: Played a chain-smoking floozy in Lynch's "Wild at Heart"; onscreen mom is played by real-life mother, Diane Ladd
- 1988: Made New York stage debut opposite then-boyfriend Kyle MacLachlan in the Off-Broadway production, "The Palace of Amateurs"
- 1988: Reteamed with Stoltz for the forced and disappointing "Haunted Summer"
- 1986: First collaboration with director David Lynch, "Blue Velvet"
- 1985: Offered an impressive performance as a sexually curious teenager in her first leading role in Joyce Chopra's "Smooth Talk"
- 1985: Attracted attention as Eric Stoltz's blind girlfriend in Peter Bogdanovich's "Mask"
- 1984: Played a young student, opposite Nick Nolte in "Teachers"
- 1983: TV-movie debut, "Happy Endings" (NBC)
- 1980: Played bit part as an irksome party crasher in Adrian Lyne's "Foxes"
- 1974: Made a brief appearance in Martin Scorsese's "Alice Doesn't Live Here Anymore"
- 1974: Returned to Los Angeles with her mother
- 1973: First feature film credit was an extra in "White Lightning"
- 1972: Made TV debut on the CBS soap opera, "The Secret Storm"; her mother played a regular on the series
- 1971: Moved to New York for three years when Diane Ladd remarried
- Petitioned to become an emancipated minor so she could work adult hours
- Raised by mother and grandmother after parents' divorce




